The focus on sustainability and effective resource management is expanding along with the upward trend in greenhouse production. Precise application of fertilizers is becoming more and more important in a variety of agricultural systems. The physical and chemical characteristics of soilless growth media differ from those of soil, which causes differences in their ability to retain nutrients. As such, accurate rates of fertilizer are crucial. This study looked at 14 different fertilizer blends with varying percentages of potassium (0-200ppm), phosphorus (0-100ppm), and nitrogen (0-200ppm). Pots were filled with Berger BM6 media and then ‘Buttercrunch’ lettuce seeds were planted. With each treatment fertilizer rate, the plants were hand-watered once a week to maintain a 10% leaching fraction. The number of leaves, dry shoot weight, fresh root weight, dried root weight, and SPAD readings were among the end measurements. The study found that a mix of high rates of nitrogen, phosphorous, potassium fertilizer treatments increased fresh shoot weight. This emphasizes the need for additional study to determine the best fertilizer rates for various specialty crops grown in soilless greenhouse environment.